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To what extent does whole genome sequencing add value above SNP arrays?
Attention conservation notice: I wrote this as the final essay for my course on personal genomics with Michael Linderman at Mt Sinai. The main question of the essay was: what is the point, in 2016, of...
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A clinical trial for omental transposition in early stage AD
A couple of years ago I wrote about treating AD with omental transposition, a radical therapy with success in ~ 35% of patients in one case series. Today I just noticed that there is a non-randomized,...
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How to do Bayesian shrinkage estimation on proportion data in Stan
Attention conservation notice: In which I once again document my slow march towards Bayesian fundamentalism. As I describe in my essay on trying to determine the best director on imdb, you usually...
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Are four postulated disease spectra due to evolutionary trade-offs?
I recently read Crespi et al.’s interesting paper on this subject. They describe eight diseases as due to four underlying diametric sets that can be explained by evolutionary/genetic trade-offs: Autism...
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Arterial aging and its relation to Alzheimer’s dementia
I’m a big proponent of the role of arterial aging in explaining dementia risk variance, in large part because it explains the large role that vascular-related risk factors have in promoting the...
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Eight years of tracking my life statistics
Attention conservation notice: Borderline obsessive navel-gazing. Most mornings, I start my day — after I lie in bed for a few minutes willing my eyes to open — by opening up a Google spreadsheet and...
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Making a shiny app to visualize brain cell type gene expression
Attention conservation notice: A post-mortem of a small side project that is probably not interesting to you unless you’re interested in molecular neuroscience. This weekend I put together an R/Shiny...
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Is progeria related to aging in the same way that familial AD is related to...
Attention conservation notice: Someone has probably made this point before. Progeria is a genetic disorder caused by mutations in the lamin A nuclear lamina protein. Since it manifests in several ways...
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Samuel Wilks on the need for multidisciplinary neurologic research (in 1864)
A history of dementia often starts in 1907 with the work of Alois Alzheimer, but in reality it should start much sooner. In 1864 Samuel Wilks wrote “Clinical Notes on the Atrophy of the Brain,” which...
View ArticleMy workflow towards the start of 2018
I’ve often found it helpful to read about how others organize and attempt to optimize their time. Here are a few of the things that I’ve been doing recently on that front, in case anyone else finds...
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